Newly discovered beneficial mutation in mitochondrial DNA seems to help Alzheimer’s gene carriers live longer
The humanin variant P3S is enriched in APOE4 centenarians. (a) Mitochondrial genomic location of the humanin smORF and the P3S ...
The humanin variant P3S is enriched in APOE4 centenarians. (a) Mitochondrial genomic location of the humanin smORF and the P3S ...
Researchers identify a mutation that alters Alzheimer's disease progression. The UMA coordinates this study, carried out by 100 multidisciplinary researchers ...
Credit: Unsplash/CC0 Public Domain A previously unidentified genetic mutation in a small protein provides significant protection against Parkinson's disease and ...
Cardiomyocytes with stained mitochondria (red), sarcomeres (green) and nuclei (blue). Credit: Klaassen Lab, Max Delbrück Center When the PRDM16 gene ...
Visual Abstract. Credit: Journal of the American Society of Nephrology (2023). DOI: 10.1681/ASN.0000000000000219 African Americans have long been known to ...
Cats sit in a shelter at the main linear park, in the capital Nicosia, Cyprus, on July 19, 2023. Cyprus’ ...
Misfolding of Acta2 p.R149C activates heat shock factor 1 (HSF1), which in turn upregulates HMG-CoA reductase (HMG-CoAR) expression and activity, ...
Credit: Gang Wang from Ruijin Hospital, affiliated to Shanghai Jiao Tong University School of Medicine Alzheimer's disease (AD) is a ...
Amiloride-sensitive Na+ currents is increased in Xenopus oocytes expressing mutant ENaCs (c.1691_1693delinsG) compared with those expressing wild-type ENaCs. Patients treated ...
Calmodulin—or CaM—is encoded by three different CALM genes. Disease CPVT-associated CaMs bind to the receptor for calcium channel in cardiomyocytes. ...